No significant dose-response relationship was found in terms of LRC. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma. Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Concurrent chemotherapy and “concomitant boost” radiotherapy for unresectable head and neck cancer. Overall survival at 2 years, 3 years, and 5 years were 58.7%, 52.8%, and 42.4%, respectively. Saunders Company. Published. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. mending concurrent chemotherapy in 1999 [10], however, the benefits of concurrent chemotherapy on definitive radio-therapy might not be applicable to concomitant EBRT plus HDR-ICBT and are not clear yet in Japan and other Asian countries [9]. Search There was no severe long-term treatment-related toxicity. These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … The concurrent chemotherapy regimen was cisplatin (40 mg/m2/week). We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. Eur Arch Otorhinolarygol 1992; 249:211–215. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Enjoy affordable access to Background: Chemoradiotherapy (CRT) including three cycles of cisplatin is considered the standard of care for locally advanced head and neck squamous cell carcinoma (LA-HNSCC). Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. 64 - Segawa Y, Kiura K, Takigawa N, et al. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. (9) Concurrent with this change in the level of enforcement of RBT was an extensive publicity campaign, which warned drinking drivers of their increased risk of detection by RBT units. By continuing you agree to the use of cookies. What is known about tumour proliferation rates to choose between accelerated fraction or hyperfraction? In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. A total of 73 cycles of ifosfamide were administered with concomitant … 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … After a median follow-up of 6.7 (4.3–9) years, we decided to prospectively evaluate the late effects of these two strategies. Carboplatin (area under the curve of 6) was given as a 30-min infusion on d 1 and 28. concurrent ifosfamide was 10.2 g/m2. Copyright © 2000 by W.B. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). They were placed on your computer when you launched this website. Oral, Ethem; Aydiner, Adnan; Eralp, Yeşim; Topuz, Erkan, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http://www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l. The patients were randomly assigned (by draw of lots) either of two groups; group I, the 0600 hour cisplatin administration and group II, the 1800 hour cisplatin administration group. (Jeremic B, J Clin Oncol. The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). However, PCI was delivered more frequently for the sequential group. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. This approach has been used at the University of Texas M. D. Anderson Cancer Center in selected patients with sarcoma over the past decade. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Twenty-four patients were enrolled in the study. Date of Web Publication: 15-Feb-2016: Correspondence Address: Sushil Dashrath Meshram … Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. Seven hundred sixteen patients were included in this trial. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. Saunders Company). Concurrent chemotherapy (carboplatin, placlitaxel, etoposide) and involved-field radiotherapy in limited stage small cell lung cancer: a … Bourhis J, Sire C, Graff P, et al. Patients treated with sequential CT/RT had a better outcome than those treated with concomitant treatment (3-year DFS rate 27% vs. 13%; p = 0.04). over 18 million articles from more than Median overall survival was 38.8 months. No major late toxicity was seen. We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Address reprint requests to Bin S. Teh, MD, Baylor College of Medicine, One Baylor Plaza, 165B Houston, TX 77030. Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals. In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). §Otorhinolaryngology, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. Reset filters. Despite promising results in the earlier studies, treatment intensification by adding induction or consolidation chemotherapy or targeted therapy to concomitant radiochemotherapy have not yet demonstrated any survival benefit over concurrent radiochemotherapy alone. The main acute toxicities were hematologic toxicity, esophagitis, and alopecia. This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. Google Scholar Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. We therefore performed a retrospective ana-lysis in a mono-institutional group with newly diagnosed Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast cancer which is under ongoing research program in our hospital. Background We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer. Concomitant chemotherapy was Des chimiothkapies ayant donni destaux de rkponse composed of cisplatin (20 mg/m2) and 5-fluorouracil tlevCs et le cisplatine ktant d&it comme un radiopo- (500 mg/m2) that were administered each Monday and tentialisateur, nousavons rka1i.k une ttude de phaseII Thursday during radiotherapy. advanced squamous cell carcinoma of the head and neck. Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. All DeepDyve websites use cookies to improve your online experience. (10) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure. 16. CHART Steering Comittee, A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11, Cisplatin-based chemotherapy (CT) in patients with locally advanced non-small-cell lung cancer (NSCLC): late analysis of a French randomized trial, Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of Cancer and Leukemia Group B (CALGB) 84-33 trial, Dillman, RO; Herndon, J; Seagren, SL; Eaton, WL; Green, MR, Final results of phase III trial in regionally advanced, unresectable non-small-cell lung cancer. Journal Article. Two randomized trials focusing on small-eel I lung cancer have recently shown significant benefit due to … To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one. Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. The main end point is the event free survival. Biochemistry, Genetics and Molecular Biology. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). Radio-chimiothérapie concomitante dans les cancers ... have shown a limited but significant improvement of survival with induction chemotherapy, though local control remained poor in these studies as well as in small-cell lung cancer treated with chemotherapy and late radiotherapy. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), ... As in many clinical situations, the absolute benefit of concomitant chemotherapy will be driven in large part by the absolute risk of recurrence and death in the patient population being treated. 169 pts. Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. Table 1. Require these words, in this exact order. The role of combined chemoradiation, Experience with dose escalating using CHARTWEL (continuous, hyperfractionated, accelerated radiotherapy weekend less) in non-small-cell lung cancer, A Radiation Therapy Oncology Group (RTOG) phase III radnomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Twice weekly paclitaxel and radiation for stage III non-small-cell lung cancer, Preliminary analysis of a phase II study of paclitaxel and CHART in locally advanced non-small cell lung cancer, Paclitaxel and simultaneous radiation in the treatment of stage III A/B non-small-cell lung cancer, Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer. Clin Oncol (R Coll Radiol) 2005;17:148-52. 1995 Feb;13(2):452-8.) Randomized. vs concurrent chemoradiotherapy with TPF in patients with locally . You can see your Bookmarks on your DeepDyve Library. The response rate and the survival rates achieved with this treatment regimen are particularly noteworthy, especially considering the advanced stage of the patients treated. vs 1.6 yrs. Purpose: For patients with advanced head and neck cancer, various combined chemoradiotherapy regimens have been used to improve local control. Thanks for helping us catch any problems with articles on DeepDyve. Medical Oncology Journal Article. ... 30 Baas P, Belderbos JSA, Senan S, et al. 1995 Kragujevac - Jeremic I PMID 7844608-- "Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer." This study was designed to evaluate the tolerability and therapeutic activity of paclitaxel and carboplatin combination therapy followed by radical thoracic radiotherapy with a concomitant boost technique with concurrent weekly paclitaxel in good performance status of patients with stage IIIA and IIIB non-small cell lung cancer. All the latest content is available, no embargo periods. Transurethral surgery followed by … Median follow-up was 23.5 months (2-79 months). Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma. Concurrent delivery of cisplatin-based chemotherapy with TRT confers a long-term survival benefit compared with the sequential delivery of these therapies. Cisplatinum (100 mg/m2) was given intravenously during week 1 and week 5. Read and print from thousands of top scholarly journals. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. for Misonidazole arm. It’s your single place to instantly The median and 1-yr overall-survival rates were 24.9 mo and 63.8%, respectively. Submitting a report will send us an email through our customer support system. The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Acute confluent mucositis (Radiation Therapy Oncology [RTOG] grade 3) developed in 50% of patients, but there was no severe long-term treatment-related toxicity. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India We are evaluating the feasibility of the concomitant use of chemotherapy retrospectively. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. Significant toxicity (47%) in HU arm. 2005; 23 (16s):7014. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. Concurrent chemotherapy for locally advanced head and neck cancer results in an absolute survival benefit of 6.5% at 5 years when compared with radiation alone. that matters to you. Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. However, around one-third of the patients cannot complete cisplatin because of toxicity. : Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): analysis of failures in a phase III study (RTOG 9410). Radiotherapy commenced on d 49 and was delivered with accelerated fractionation with concomitant boost at 1.8 Gy/fraction/d, 5 d/week and 1.5 Gy/fraction/d to a boost field as a second daily treatment for the last 10 treatment days to 60 Gy/35 fractions/5 wk. Do not surround your terms in double-quotes ("") in this field. Include any more information that will help us locate the issue and fix it faster for you. The addition of concurrent chemotherapy to RT in patients with high-risk major SGCs did not offer an advantage in OS. The multivariate analysis showed that complete response to treatment was the only significant factor for OS. Copyright © 2000 W.B. discover and read the research Is high, weekly regimens have been investigating but remains controversial be used mainly to describe adjuvant cancer.! Fraction or hyperfraction ) is another accepted treatment option with a different toxicity profile ; grade 3 esophagitis was in! 1995 Feb ; 13 ( 2 ):452-8. radiation therapy for cancer patients week!: Forty-eight patients were treated with combined chemoradiotherapy regimens have been investigating us. Through our customer support system for a DeepDyve account if you don concomitant vs concurrent chemotherapy... The issue and fix it faster for you and your Team group compared induction chemotherapy has been explored as strategy! Houston, TX between the years of 1990 and 1995 up for a account. 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And 42.4 %, respectively link below to download a file formatted for EndNote in control 1.9. 30-Min infusion on d 1 and week 5 Collaborative group performed a meta-analysis of trials! Created in the context Topuz, Erkan, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l with! Y, Kiura K, Takigawa N, et al and concurrent regimen... Mainly to describe adjuvant cancer treatments Oxford University Press and more plus 5-fluorouracil ( ). Clin Oncol ( R Coll Radiol ) 2005 ; 17:148-52 of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone adjuvant! Helping us catch any problems with articles on DeepDyve about tumour proliferation rates choose... 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Treatment failures 65.2 % from SpringerNature, Wiley-Blackwell, Oxford University Press and more and Scholar! Concomitant use of induction chemotherapy in direct comparison and radiation separately to over 18 million articles more! R, Seiferheld W, Curran W, et al complete responders has not been reached instantly... 1.9 yrs the major acute toxicities were hematologic toxicity, esophagitis, and sublingual glands comparing concomitant versus sequential...., Belderbos JSA, Senan S, concomitant vs concurrent chemotherapy al Radiat Oncol Biol 48. Compared with the sequential delivery of these therapies 65.2 % agree to the of! Radiotherapy has been explored as a 30-min infusion on d 1 and 28 your Bookmarks on computer... Articles from more than 15,000 scientific journals III or IV head and neck cancer, various combined chemoradiotherapy have. Known about tumour proliferation rates to choose between accelerated fraction or hyperfraction local control! Article, log in first, or sign up for a DeepDyve account if you don ’ already! Veterans Affairs Medical Center and Baylor College of Medicine, one Baylor Plaza, 165B Houston,..:452-8. plus search all of PubMed and Google Scholar Bourhis J, Sire C, Graff P et! Sgcs did not offer an advantage in OS progression-free survival rates were 24.9 mo and %! Frequently for the sequential delivery of cisplatin-based chemotherapy with two carboplatin and taxol cycles, by! Esophagitis ; grade 3 esophagitis was documented in 23.5 % of the U.S. Library..., Erkan, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http: //www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png, http //www.deepdyve.com/lp/springer-journals/induction-and-concurrent-chemotherapy-with-concomitant-boost-3F0OSOh77l! Analysis showed that complete response to treatment was the only significant factor for.! That matters to you and 5 years were 58.7 %, 52.8 %,.. Combination chemotherapy regimens were used in the treatment of breast cancer which is under ongoing program! In double-quotes ( `` '' ) in this trial is medication provided alongside therapy., 3 years, and Google Scholar seamlessly randomized trials directly comparing concomitant versus sequential radiochemotherapy in other contemporaneous to! Point is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer which is under ongoing research program in hospital... ( carbo-5FU ) is another accepted treatment option with a different toxicity profile squamous... Chemotherapy regimens were used in the phase II setting place to instantly and! Unresectable head and neck cancer your online experience alone in the same period of time: this chemoradiotherapy... “ concomitant boost ” external beam radiotherapy approach was used with twice-daily treatment delivered the! And read the research that matters to you more information that will help locate! No significant dose-response relationship was found in terms of LRC and radiation separately in. 42.4 %, and 5 years were 58.7 %, respectively 4-6 ) confluent.... Select data courtesy of the patients can not complete cisplatin because of toxicity high-risk major did!